Asda will become the first UK supermarket to offer Covid-19 vaccinations starting from January 25.
The supermarket said it was chosen by NHS England to operate a vaccination centre from one of its in-store pharmacies in Birmingham and will be administered by qualified Asda staff.
The company's president, Roger Burnley, said: "We are incredibly proud to provide this service and are keen to do all we can to help the NHS and government accelerate the roll out of the vaccination programme.
We have an extensive nationwide logistics network that could support the storage and distribution of the vaccine and our highly-trained pharmacy colleagues are experienced in delivering large vaccination programmes, having recently provided nearly 200,000 flu jabs to members of the public."
Priority groups will receive the Pfizer-BioNTech vaccine and people will receive an appointment from the National Health Service (NHS).
The store will have capacity to administer about 250 jabs every day.
The supermarket firm said it would not reveal which store has been selected until closer to the time on the advice of NHS England because of concerns staff would be bombarded with requests for appointments.