England players will hold talks with the England and Wales Cricket Board (ECB) this week over concerns they may be forced to leave their families behind for the Ashes series later this year.
With the visiting team facing a gruelling months-long schedule likely to be subject to a host of pandemic-related restrictions, Vaughan said some players may choose not to make the trip if they cannot see their loved ones for such a long time.
The first Ashes Test in Brisbane begins on 8 December, but players who also take part in the T20 World Cup - starting in October - are due to leave the UK in mid-September.
They would then potentially not return home until after the final Test in Perth ends on 18 January.
Australia has imposed strict cap on the number of people entering the country throughout the pandemic and states have been quick to close their borders to prevent interstate movement.
England are due to leave for Bangladesh, where they will begin their preparations for the T20 World Cup in the United Arab Emirates and Oman, on about 19 September.
Those taking part in the Ashes will head to Australia after the World Cup, which ends on 14 November.
They will join a group of red-ball specialists who will leave the UK in early November.
All members of the England party will be required to quarantine for 14 days when they enter Australia, regardless of where they arrive from.
Australia players who take part in the T20 World Cup will be in the same situation.
England are set to warm up for the Ashes with a series of intra-squad matches also involving England Lions.
Families have traditionally joined the players for at least part of such tours in past but with more than half of Australia’s population in lockdown and concerns about the spread of the Delta variant of Covid-19 the number one issue in the country, it could be difficult for politicians to grant exemptions for travel.